TTG

Test investigation

TTG

Laboratory offering test

NNUH

Units

IU/mL

Also known as/Frequency of test

Coeliac Antibodies, IgA tissue Transglutaminase (IgA Ttg) or Endomysial Antibodies; Endomysium Antibodies; IgA Endomysial Antibodies

Indications

IgA tTg is the first line test for coeliac disease; a positive result should be confirmed with a request for EMA. If IgA deficiency is suspected (laboratory findings) total immunoglobulin/electrophoresis and IgG tTG will be requested. All these tests have a good sensitivity and specificity for Coeliac disease if the patient is on a gluten containing diet (2 gluten containing meals daily for 6 weeks)

Sample type

Serum

Turnaround times (TAT) Urgent/Routine/GP or OPD

2 working days

Reference intervals

0.0 – 7.0 IU/mL Negative 7.0 – 10.0 IU/mL Equivocal > 10.0 IU/mL Positive