Procollagen-3 N-Terminal Peptide (PIIINP, P3NP)

Test/Investigation

Procollagen-3 N-Terminal Peptide (PIIINP, P3NP)

Site(s) or Laboratory offering Test/Investigation

QEH

Units

ug/L

Comments/Precautions

The decision to perform biopsy, withdraw treatment, or continue treatment despite raised PIIINP concentrations, must also take into account other factors, such as disease severity, patient age, and the ease with which alternative therapies may be used in place of methotrexate.

Sample type

Serum

Turnaround times (TAT) Urgent/Routine/GP or OPD

3-4 weeks

Reference intervals (adult unless stated)

Indications for liver biopsy
Pre-treatment > 13.0 ug/L
During treatment > 7.0 ug/L in at least 3 samples over 12 months
During treatment > 13.0 ug/L in 2 consecutive samples

Indications for withdrawal of methotrexate:
During treatment > 17.0 ug/L in at least 3 samples over 12 months