ANCA

Test/Investigation

ANCA

Site(s) or Laboratory offering Test/Investigation

NNUH

Units

IU/mL

Also Known as/Frequency of Test

Neutrophil Cytoplasmic Antibodies, MPO/PR3; c-ANCA; p-ANCA

Indications

MPO and PR3 antibodies are associated with the systemic necrotising vasculitides Granulomatous Polyangitis (GPA/Wegener's Granulomatosis), Microscopic Polyarteritis, Rapidly Progressive Glomerulonephritis and Churg-Strauss Syndrome

Comments/Precautions

MPO PR3 ANCA immunofluorescence

Sample type

Serum

Turnaround times (TAT) Urgent/Routine/GP or OPD

2 working days

Reference intervals (adult unless stated)

MPO <3.5 IU/mL Negative
3.5 – 5.0 IU/mL Equivocal
>5.0 IU/mL Positive. PR3 <2.0 IU/mL Negative
2.0 – 3.0 IU/mL Equivocal
>3.0 IU/mL Positive
ANCA immunofluorescence Negative

If UKAS Accredited Test indicate at which site

Y NNUH