rocollagen-3 N-Terminal Peptide (PIIINP, P3NP)

Test investigation

rocollagen-3 N-Terminal Peptide (PIIINP, P3NP)

Laboratory offering test




Comments precautions

The decision to perform biopsy, withdraw treatment, or continue treatment despite raised PIIINP concentrations, must also take into account other factors, such as disease severity, patient age, and the ease with which alternative therapies may be used in place of methotrexate.

Sample type


Turnaround times (TAT) Urgent/Routine/GP or OPD

4-6 weeks

Reference intervals

Indications for liver biopsy Pre-treatment > 13.0 ug/L During treatment > 7.0 ug/L in at least 3 samples over 12 months During treatment > 13.0 ug/L in 2 consecutive samples Indications for withdrawal of methotrexate: During treatment > 17.0 ug/L in at least 3 samples over 12 months